OREGON STATE UNIVERSITY
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| Title | Evolution of 'design' principles in biochemical networks. |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | de Atauri, P, Orrell, D, Ramsey, SA, Bolouri, H |
| Journal | Syst Biol (Stevenage) |
| Volume | 1 |
| Issue | 1 |
| Pagination | 28-40 |
| Date Published | 2004 Jun |
| ISSN | 1741-2471 |
| Keywords | Adaptation, Physiological, Biochemistry, Biological Evolution, Computer Simulation, Evolution, Molecular, Galactose, Gene Expression Regulation, Fungal, Models, Genetic, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Signal Transduction |
| Abstract | Computer modelling and simulation are commonly used to analyse engineered systems. Biological systems differ in that they often cannot be accurately characterised, so simulations are far from exact. Nonetheless, we argue in this paper that evolution results in recurring, dynamic organisational principles in biological systems, and that simulation can help to identify them and analyse their dynamic properties. As a specific example, we present a dynamic model of the galactose utilisation pathway in yeast, and highlight several features of the model that embody such 'design principles'. |
| DOI | 10.1049/sb:20045013 |
| Alternate Journal | Syst Biol (Stevenage) |
| PubMed ID | 17052113 |