|Title||The extent of the uptake of plasmid into the skin determines the immune responses induced by a DNA vaccine applied topically onto the skin. |
|Publication Type||Journal Article |
|Year of Publication||2011 |
|Authors||Yu, Z, Chung, W-G, Sloat, BR, Löhr, CV, Weiss, R, B Rodriguez, L, Li, X, Cui, Z |
|Journal||The Journal of pharmacy and pharmacology |
|Date Published||2011 Feb |
Non-invasive immunization by application of plasmid DNA topically onto the skin is an attractive immunization approach. However, the immune responses induced are generally weak. Previously, we showed that the antibody responses induced by topical DNA vaccine are significantly enhanced when hair follicles in the application area are induced into the anagen (growth) stage by hair plucking. In the present study, we further investigated the mechanism of immune enhancement.