TitleHarnessing the gut microbiome in the fight against anthelminthic drug resistance.
Publication TypeJournal Article
Year of Publication2020
AuthorsSharpton, TJ, Combrink, L, Arnold, HK, Gaulke, CA, Kent, ML
JournalCurr Opin Microbiol
Date Published2020 02
KeywordsAnimals, Anthelmintics, Drug Resistance, Gastrointestinal Microbiome, Helminthiasis, Helminths, Humans, Intestinal Diseases, Parasitic

Intestinal helminth parasites present major challenges to the welfare of humans and threaten the global food supply. While the discovery of anthelminthic drugs empowered our ability to offset these harms to society, the alarming rise of anthelminthic drug resistance mitigates contemporary efforts to treat and control intestinal helminthic infections. Fortunately, emerging research points to potential opportunities to combat anthelminthic drug resistance by harnessing the gut microbiome as a resource for discovering novel therapeutics and informing responsible drug administration. In this review, we highlight research that demonstrates this potential and provide rationale to support increased investment in efforts to uncover and translationally utilize knowledge about how the gut microbiome mediates intestinal helminthic infection and its outcomes.

Alternate JournalCurr Opin Microbiol
PubMed ID32114334
PubMed Central IDPMC7722764
Grant ListR21 AI135641 / AI / NIAID NIH HHS / United States
R24 OD010998 / OD / NIH HHS / United States