TitleImmune stability predicts tuberculosis infection risk in a wild mammal.
Publication TypeJournal Article
Year of Publication2019
AuthorsSeguel, M, Beechler, B, Coon, CC, Snyder, PW, Spaan, JM, Jolles, AE, Ezenwa, VO
JournalProc Biol Sci
Volume286
Issue1912
Pagination20191401
Date Published2019 10 09
ISSN1471-2954
KeywordsAnimals, Buffaloes, Disease Susceptibility, Immunity, Innate, Interferon-gamma, Tuberculosis
Abstract

Immunity is one of the most variable phenotypic traits in animals; however, some individuals may show less fluctuation in immune traits, resulting in stable patterns of immune variation over time. It is currently unknown whether immune variation has consequences for infectious disease risk. In this study, we identified moderately stable immune traits in wild African buffalo and asked whether the stability of these traits affected bovine tuberculosis (TB) infection risk. We found that adaptive immune traits such as the level of interferon-γ (IFN-γ) released after white blood cell stimulation, the number of circulating lymphocytes and the level of antibodies against bovine adenovirus-3 were moderately repeatable (i.e. stable) over time, whereas parameters related to innate immunity either had low repeatability (circulating eosinophil numbers) or were not repeatable (e.g. neutrophil numbers, plasma bacteria killing capacity). Intriguingly, individuals with more repeatable IFN-γ and lymphocyte levels were at a significantly higher risk of acquiring TB infection. In stark contrast, average IFN-γ and lymphocyte levels were poor predictors of TB risk, indicating that immune variability rather than absolute response level better captured variation in disease susceptibility. This work highlights the important and under-appreciated role of immune variability as a predictor of infection risk.

DOI10.1098/rspb.2019.1401
Alternate JournalProc Biol Sci
PubMed ID31575363
PubMed Central IDPMC6790785
Grant ListR01 GM131319 / GM / NIGMS NIH HHS / United States