TitleInterplay between viruses and bacterial microbiota in cancer development.
Publication TypeJournal Article
Year of Publication2017
AuthorsVyshenska, D, Lam, KC, Shulzhenko, N, Morgun, A
JournalSemin Immunol
Date Published2017 08
KeywordsAnimals, Carcinogenesis, Gene-Environment Interaction, Humans, Microbiota, Neoplasms, Oncogenic Viruses, Viral Load, Virus Diseases

During the last few decades we have become accustomed to the idea that viruses can cause tumors. It is much less considered and discussed, however, that most people infected with oncoviruses will never develop cancer. Therefore, the genetic and environmental factors that tip the scales from clearance of viral infection to development of cancer are currently an area of active investigation. Microbiota has recently emerged as a potentially critical factor that would affect this balance by increasing or decreasing the ability of viral infection to promote carcinogenesis. In this review, we provide a model of microbiome contribution to the development of oncogenic viral infections and viral associated cancers, give examples of this process in human tumors, and describe the challenges that prevent progress in the field as well as their potential solutions.

Alternate JournalSemin Immunol
PubMed ID28602713
PubMed Central IDPMC5685535
Grant ListR01 DK103761 / DK / NIDDK NIH HHS / United States
U01 AI109695 / AI / NIAID NIH HHS / United States