|Title||Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats. |
|Publication Type||Journal Article |
|Year of Publication||2009 |
|Authors||Stratmann, G, Sall, JW, May, LDV, Bell, JS, Magnusson, KR, Rau, V, Visrodia, KH, Alvi, RS, Ku, B, Lee, MT, Dai, R |
|Date Published||2009 Apr |
|Keywords||Treatment Outcome |
Anesthetic agents cause cell death in the developing rodent brain and long-term, mostly hippocampal-dependent, neurocognitive dysfunction. However, a causal link between these findings has not been shown. Postnatal hippocampal neurogenesis affects hippocampal function into adulthood; therefore, the authors tested the hypothesis that isoflurane affects long-term neurocognitive function via an effect on dentate gyrus neurogenesis.