TitleIsoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats.
Publication TypeJournal Article
Year of Publication2009
AuthorsStratmann, G, Sall, JW, May, LDV, Bell, JS, Magnusson, KR, Rau, V, Visrodia, KH, Alvi, RS, Ku, B, Lee, MT, Dai, R
Date Published2009 Apr
KeywordsTreatment Outcome

Anesthetic agents cause cell death in the developing rodent brain and long-term, mostly hippocampal-dependent, neurocognitive dysfunction. However, a causal link between these findings has not been shown. Postnatal hippocampal neurogenesis affects hippocampal function into adulthood; therefore, the authors tested the hypothesis that isoflurane affects long-term neurocognitive function via an effect on dentate gyrus neurogenesis.