| Title | Isoflurane differentially affects neurogenesis and long-term neurocognitive function in 60-day-old and 7-day-old rats. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Stratmann, G, Sall, JW, May, LDV, Bell, JS, Magnusson, KR, Rau, V, Visrodia, KH, Alvi, RS, Ku, B, Lee, MT, Dai, R |
| Journal | Anesthesiology |
| Volume | 110 |
| Issue | 4 |
| Pagination | 834-48 |
| Date Published | 2009 Apr |
| Keywords | Treatment Outcome |
| Abstract | Anesthetic agents cause cell death in the developing rodent brain and long-term, mostly hippocampal-dependent, neurocognitive dysfunction. However, a causal link between these findings has not been shown. Postnatal hippocampal neurogenesis affects hippocampal function into adulthood; therefore, the authors tested the hypothesis that isoflurane affects long-term neurocognitive function via an effect on dentate gyrus neurogenesis.
|
OREGON STATE UNIVERSITY
Open search box