TitleLcrG is required for efficient translocation of Yersinia Yop effector proteins into eukaryotic cells.
Publication TypeJournal Article
Year of Publication1998
AuthorsSarker, MR, Sory, MP, Boyd, AP, Iriarte, M, Cornelis, GR
JournalInfection and immunity
Date Published1998 Jun
KeywordsYersinia enterocolitica

Extracellular Yersinia disables the immune system of its host by injecting effector Yop proteins into host cells. We show that a Yersinia enterocolitica nonpolar lcrG mutant is severely impaired in the translocation of YopE, YopH, YopM, YpkA/YopO, and YopP into eukaryotic cells. LcrG is thus required for efficient internalization of all the known Yop effectors.