Title | Long-term outcomes of dogs undergoing surgical resection of mast cell tumors and soft tissue sarcomas: A prospective 2-year-long study. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Milovancev, M, Townsend, KL, Tuohy, JL, M Gorman, E, Bracha, S, Curran, KM, Russell, DS |
Journal | Vet Surg |
Volume | 49 |
Issue | 1 |
Pagination | 96-105 |
Date Published | 2020 Jan |
ISSN | 1532-950X |
Keywords | Animals, Disease-Free Survival, Dog Diseases, Dogs, Female, Longitudinal Studies, Male, Margins of Excision, Mastocytoma, Neoplasm Recurrence, Local, Prospective Studies, Sarcoma, Soft Tissue Neoplasms, Surgery, Veterinary |
Abstract | OBJECTIVE: Report clinical outcomes of dogs with surgically excised mast cell tumors (MCT) and soft tissue sarcomas (STS). STUDY DESIGN: Prospective clinical study. SAMPLE POPULATION: Fifty-three dogs with 52 MCT (50 low grade, 2 high grade) and 19 STS (12 grade I, 6 grade II, 1 grade III). METHODS: All dogs were examined at 3, 6, 12, 18, and 24 months postoperatively, with cytologic or histopathologic evaluation of suspected local recurrences. Dogs euthanized because of study tumor-related causes underwent necropsy. RESULTS: Median intraoperative margins were 20 mm and 30 mm wide for MCT and STS, respectively, with 1 fascial plane resected en bloc. The narrowest histologic tumor-free margins measured <1 mm in 21 of 52 (40%) MCT and 7 of 19 (37%) STS. All dogs were followed for 24 months. Two of 50 (4%) low-grade MCT were diagnosed, with local recurrence 181 and 265 days postoperatively. Two of 36 (6%) dogs with low-grade MCT developed visceral metastasis 181 and 730 days postoperatively. One of 2 dogs with high-grade MCT developed local recurrence 115 days postoperatively. No local recurrence or metastasis was diagnosed after excision of 19 STS. CONCLUSION: Local recurrence rates among predominantly low- to intermediate-grade MCT and STS were low, despite a high prevalence of histologic tumor-free margins <1 mm. Surgical recommendations for high-grade tumors cannot be extrapolated from this population. CLINICAL SIGNIFICANCE: Surgeons should seek to achieve microscopically complete excision for MCT and STS while minimizing patient morbidity and considering limitations of histopathology in predicting outcomes. |
DOI | 10.1111/vsu.13225 |
Alternate Journal | Vet Surg |
PubMed ID | 31044443 |
Grant List | / / Oregon State University / / / American College of Veterinary Surgeons Foundation / |