TitleMycobacterium avium uses apoptotic macrophages as tools for spreading.
Publication TypeJournal Article
Year of Publication2011
AuthorsEarly, J, Fischer, KA, Bermudez, LE
JournalMicrobial pathogenesis
Volume50
Issue2
Pagination132-9
Date Published2011 Feb
KeywordsMycobacterium avium-intracellulare Infection
Abstract

Mycobacterium avium (MAC) lives and replicates in macrophages and causes disseminated disease in immunocompromised individuals. As a host response to control disease, many macrophages become apoptotic a few days after MAC infection. In this study, we hypothesized that MAC can survive autophagic and apoptotic macrophages and spread.
DOI10.1111/j.1365-3164.2011.00980.x