|Title||Origins and functions of the chlamydial inclusion. |
|Publication Type||Journal Article |
|Year of Publication||1997 |
|Authors||Hackstadt, T, Fischer, ER, Scidmore, MA, Rockey, DD, Heinzen, RA |
|Journal||Trends in microbiology |
|Date Published||1997 Jul |
|Keywords||Biological, Models |
Chlamydiae dissociate themselves from the endocytic pathway shortly after internalization by actively modifying the vacuole to become fusogenic with sphingomyelin-containing exocytic vesicles. Interaction with this secretory pathway appears to provide a pathogenic mechanism that allows chlamydiae to establish themselves in a site that is not destined to fuse with lysosomes.