TitleOrigins and functions of the chlamydial inclusion.
Publication TypeJournal Article
Year of Publication1997
AuthorsHackstadt, T, Fischer, ER, Scidmore, MA, Rockey, DD, Heinzen, RA
JournalTrends in microbiology
Volume5
Issue7
Pagination288-93
Date Published1997 Jul
KeywordsBiological, Models
Abstract

Chlamydiae dissociate themselves from the endocytic pathway shortly after internalization by actively modifying the vacuole to become fusogenic with sphingomyelin-containing exocytic vesicles. Interaction with this secretory pathway appears to provide a pathogenic mechanism that allows chlamydiae to establish themselves in a site that is not destined to fuse with lysosomes.

DOI10.1016/S0966-842X(97)01061-5