| Title | Origins and functions of the chlamydial inclusion. |
| Publication Type | Journal Article |
| Year of Publication | 1997 |
| Authors | Hackstadt, T, Fischer, ER, Scidmore, MA, Rockey, DD, Heinzen, RA |
| Journal | Trends Microbiol |
| Volume | 5 |
| Issue | 7 |
| Pagination | 288-93 |
| Date Published | 1997 Jul |
| ISSN | 0966-842X |
| Keywords | Biological Transport, Active, Cell Membrane, Chlamydia Infections, Chlamydia trachomatis, Endocytosis, Humans, Inclusion Bodies, Membrane Fusion, Models, Biological |
| Abstract |
Chlamydiae dissociate themselves from the endocytic pathway shortly after internalization by actively modifying the vacuole to become fusogenic with sphingomyelin-containing exocytic vesicles. Interaction with this secretory pathway appears to provide a pathogenic mechanism that allows chlamydiae to establish themselves in a site that is not destined to fuse with lysosomes.
|
| DOI | 10.1016/S0966-842X(97)01061-5 |
| Alternate Journal | Trends Microbiol |
| PubMed ID | 9234512 |
OREGON STATE UNIVERSITY
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