Title | Perspective on animal models: chronic intracellular infections. |
Publication Type | Journal Article |
Year of Publication | 2001 |
Authors | Young, LS, Bermudez, LE |
Journal | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America |
Volume | 33 Suppl 3 |
Pagination | S221-6 |
Date Published | 2001 Sep 15 |
Keywords | Predictive Value of Tests |
Abstract | Systemic human disease caused by organisms of the Mycobacterium avium-Mycobacterium intracellulare complex (MAC) represent a chronic intracellular infection in human hosts who are usually immunocompromised. To develop improved treatment and prophylaxis, and to obtain a better understanding of pathogenesis, we studied the beige mouse (C57 beige(+)/beige(+)) challenged orally or intravenously with a human isolate that causes lethal disease in patients with AIDS (MAC 101, serovar 1). Encouraging anti-MAC studies in animals, as reviewed here, should provide the basis for considering human trials with a promising agent. The ability of an antimicrobial agent to achieve high intracellular concentrations has correlated with the in vivo activity of several specific compounds. |
DOI | 10.1086/321851 |