| Title | Post-surgical outcome and prognostic factors in canine malignant melanomas of the haired skin: 87 cases (2003-2015). |
| Publication Type | Journal Article |
| Year of Publication | 2018 |
| Authors | Laver, T, Feldhaeusser, BR, Robat, CS, Baez, JL, Cronin, KL, Buracco, P, Annoni, M, Regan, RC, McMillan, SK, Curran, KM, Selmic, LE, Shiu, K-B, Clark, K, Fagan, E, Thamm, DH |
| Journal | Can Vet J |
| Volume | 59 |
| Issue | 9 |
| Pagination | 981-987 |
| Date Published | 2018 09 |
| ISSN | 0008-5286 |
| Keywords | Age Factors, Animals, Dog Diseases, Dogs, Female, Male, Melanoma, Neoplasm Metastasis, Prognosis, Retrospective Studies, Skin Neoplasms, Survival Analysis |
| Abstract |
The medical records of 87 dogs treated with surgery for cutaneous malignant melanoma (CMM) of the haired skin were retrospectively reviewed for overall survival time (OST), progression-free survival time (PFS), and prognostic factors. The post-surgery median PFS and median OST were 1282 days and 1363 days, respectively. The post-surgery metastatic rate was 21.8% with a local recurrence rate of 8%. Increasing mitotic index (MI) was predictive of a significantly decreased OST and PFS on multivariable analysis [hazard ratio (HR): 1.05, 95% confidence interval (CI): 1.02 to 1.07 and HR: 1.04, 95% CI: 1.02 to 1.06, respectively]. Increasing age was likewise predictive of a significantly decreased OST and PFS on multivariable analysis (HR: 1.39, 95% CI: 1.17 to 1.65 and HR: 1.33, 95% CI: 1.14 to 1.54, respectively). These results confirm clinical impressions that long survival times are likely in dogs diagnosed with malignant melanoma of the haired skin when treated with surgery alone.
|
| Alternate Journal | Can Vet J |
| PubMed ID | 30197441 |
| PubMed Central ID | PMC6091115 |
OREGON STATE UNIVERSITY
Open search box