TitlePost-surgical outcome and prognostic factors in canine malignant melanomas of the haired skin: 87 cases (2003-2015).
Publication TypeJournal Article
Year of Publication2018
AuthorsLaver, T, Feldhaeusser, BR, Robat, CS, Baez, JL, Cronin, KL, Buracco, P, Annoni, M, Regan, RC, McMillan, SK, Curran, KM, Selmic, LE, Shiu, K-B, Clark, K, Fagan, E, Thamm, DH
JournalCan Vet J
Volume59
Issue9
Pagination981-987
Date Published2018 Sep
ISSN0008-5286
Abstract

The medical records of 87 dogs treated with surgery for cutaneous malignant melanoma (CMM) of the haired skin were retrospectively reviewed for overall survival time (OST), progression-free survival time (PFS), and prognostic factors. The post-surgery median PFS and median OST were 1282 days and 1363 days, respectively. The post-surgery metastatic rate was 21.8% with a local recurrence rate of 8%. Increasing mitotic index (MI) was predictive of a significantly decreased OST and PFS on multivariable analysis [hazard ratio (HR): 1.05, 95% confidence interval (CI): 1.02 to 1.07 and HR: 1.04, 95% CI: 1.02 to 1.06, respectively]. Increasing age was likewise predictive of a significantly decreased OST and PFS on multivariable analysis (HR: 1.39, 95% CI: 1.17 to 1.65 and HR: 1.33, 95% CI: 1.14 to 1.54, respectively). These results confirm clinical impressions that long survival times are likely in dogs diagnosed with malignant melanoma of the haired skin when treated with surgery alone.

Alternate JournalCan. Vet. J.
PubMed ID30197441
PubMed Central IDPMC6091115