TitleIs the regulation of galactose 1-phosphate tuned against gene expression noise?
Publication TypeJournal Article
Year of Publication2005
Authorsde Atauri, P, Orrell, D, Ramsey, SA, Bolouri, H
JournalBiochem J
IssuePt 1
Date Published2005 Apr 01
KeywordsGalactose, Galactosephosphates, Gene Expression Regulation, Fungal, Kinetics, Protein Biosynthesis, RNA, Fungal, RNA, Messenger, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Transcription, Genetic, UTP-Hexose-1-Phosphate Uridylyltransferase

The average number of mRNA molecules per active gene in yeast can be remarkably low. Consequently, the relative number of copies of each transcript per cell can vary greatly from moment to moment. When these transcripts are encoding metabolic enzymes, how do the resulting variations in enzyme concentrations affect the regulation of metabolic intermediates? Using a kinetic model of galactose utilization in yeast, we analysed the transmission of noise from transcription and translation on metabolic intermediate regulation. In particular, the effect of the kinetic properties of the galactose-1-phosphate uridylyltransferase reaction on the transmission of noise was analysed.

Alternate JournalBiochem J
PubMed ID15506917
PubMed Central IDPMC1134934