| Title | Is the regulation of galactose 1-phosphate tuned against gene expression noise? |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | de Atauri, P, Orrell, D, Ramsey, SA, Bolouri, H |
| Journal | Biochem J |
| Volume | 387 |
| Issue | Pt 1 |
| Pagination | 77-84 |
| Date Published | 2005 Apr 01 |
| ISSN | 1470-8728 |
| Keywords | Galactose, Galactosephosphates, Gene Expression Regulation, Fungal, Kinetics, Protein Biosynthesis, RNA, Fungal, RNA, Messenger, Saccharomyces cerevisiae, Saccharomyces cerevisiae Proteins, Transcription, Genetic, UTP-Hexose-1-Phosphate Uridylyltransferase |
| Abstract |
The average number of mRNA molecules per active gene in yeast can be remarkably low. Consequently, the relative number of copies of each transcript per cell can vary greatly from moment to moment. When these transcripts are encoding metabolic enzymes, how do the resulting variations in enzyme concentrations affect the regulation of metabolic intermediates? Using a kinetic model of galactose utilization in yeast, we analysed the transmission of noise from transcription and translation on metabolic intermediate regulation. In particular, the effect of the kinetic properties of the galactose-1-phosphate uridylyltransferase reaction on the transmission of noise was analysed.
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| DOI | 10.1042/BJ20041001 |
| Alternate Journal | Biochem J |
| PubMed ID | 15506917 |
| PubMed Central ID | PMC1134934 |
OREGON STATE UNIVERSITY
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