Title | A RhoA-derived peptide inhibits human immunodeficiency virus-1 entry in vitro. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Maselko, M, Ward, C, Pastey, M |
Journal | Current HIV research |
Volume | 9 |
Issue | 1 |
Pagination | 1-5 |
Date Published | 2011 Jan 1 |
Keywords | Virus Internalization |
Abstract | RhoA-derived peptides have been shown to have antiviral activity against both human respiratory syncytial virus and human parainfluenza virus-3. The present study investigates the toxicity, anti-HIV-1 activity and mechanism of action of a RhoA-derived peptide (RhoA 77-95). The efficacy of this peptide was compared to a scrambled peptide of the same amino acid composition and Enfuvirtide, a HIV entry inhibitor. Our data show that this RhoA-derived peptide is a non-toxic and effective inhibitor of a CXCR4 tropic strain of HIV-1. We also demonstrate that the mechanism of entry inhibition is likely mediated by polyanionic properties and is dependent on the dimerization of peptides. |
DOI | 10.1111/j.1365-3164.2011.00980.x |