OREGON STATE UNIVERSITY
Open search box
| Title | A RhoA-derived peptide inhibits syncytium formation induced by respiratory syncytial virus and parainfluenza virus type 3. |
| Publication Type | Journal Article |
| Year of Publication | 2000 |
| Authors | Pastey, M, Gower, TL, Spearman, PW, Crowe, JE, Graham, BS |
| Journal | Nature medicine |
| Volume | 6 |
| Issue | 1 |
| Pagination | 35-40 |
| Date Published | 2000 Jan |
| Keywords | Vaccinia virus |
| Abstract | The fusion glycoproteins of human respiratory syncytial virus (RSV) and human parainfluenza virus type-3 (PIV-3) mediate virus entry and syncytium formation. Interaction between the fusion protein of RSV and RhoA, a small GTPase, facilitates virus-induced syncytium formation. We show here a RhoA-derived peptide inhibits RSV and syncytium formation induced by RSV and PIV-3, both in vitro by inhibition of cell-to-cell fusion and in vivo by reduction of peak titer by 2 log10 in RSV-infected mice. These findings indicate that the interaction between these two paramyxovirus fusion proteins and RhoA is an important target for new antiviral strategies. |