TitleRole of gut microbiota in type 2 diabetes pathophysiology.
Publication TypeJournal Article
Year of Publication2020
AuthorsGurung, M, Li, Z, You, H, Rodrigues, R, Jump, DB, Morgun, A, Shulzhenko, N
Date Published2020 Jan
KeywordsBacteria, Diabetes Mellitus, Type 2, Gastrointestinal Microbiome, Humans

A substantial body of literature has provided evidence for the role of gut microbiota in metabolic diseases including type 2 diabetes. However, reports vary regarding the association of particular taxonomic groups with disease. In this systematic review, we focused on the potential role of different bacterial taxa affecting diabetes. We have summarized evidence from 42 human studies reporting microbial associations with disease, and have identified supporting preclinical studies or clinical trials using treatments with probiotics. Among the commonly reported findings, the genera of Bifidobacterium, Bacteroides, Faecalibacterium, Akkermansia and Roseburia were negatively associated with T2D, while the genera of Ruminococcus, Fusobacterium, and Blautia were positively associated with T2D. We also discussed potential molecular mechanisms of microbiota effects in the onset and progression of T2D.

Alternate JournalEBioMedicine
PubMed ID31901868
PubMed Central IDPMC6948163
Grant ListR01 DK103761 / DK / NIDDK NIH HHS / United States
R01 DK112360 / DK / NIDDK NIH HHS / United States