OREGON STATE UNIVERSITY
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| Title | SRI-286, a thiosemicarbazole, in combination with mefloquine and moxifloxacin for treatment of murine Mycobacterium avium complex disease. |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Bermudez, LE, Kolonoski, P, Seitz, LE, Petrofsky, M, Reynolds, R, Wu, M, Young, LS |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 48 |
| Issue | 9 |
| Pagination | 3556-8 |
| Date Published | 2004 Sep |
| Keywords | Thioacetazone |
| Abstract | Treatment of Mycobacterium avium disease remains challenging when macrolide resistance develops. We infected C57 beige mice and treated them with mefloquine, SRI-286, and moxifloxacin. SRI-286 (80 mg/kg) was bactericidal in the liver. Mefloquine plus moxifloxacin or mefloquine plus SRI-286 were better than mefloquine alone. |
| DOI | 10.1128/AAC.48.9.3556-3558.2004 |