TitleA systems biology approach to understanding atherosclerosis.
Publication TypeJournal Article
Year of Publication2010
AuthorsRamsey, SA, Gold, ES, Aderem, A
JournalEMBO Mol Med
Date Published2010 Mar
KeywordsAtherosclerosis, Gene Expression Profiling, Gene Expression Regulation, Genomics, Humans, Models, Biological, Proteomics, Systems Biology

Atherosclerosis, a chronic inflammatory disease of the vascular system, presents significant challenges to developing effective molecular diagnostics and novel therapies. A systems biology approach integrating data from large-scale measurements (e.g. transcriptomics, proteomics and genomics) is successfully contributing to deciphering regulatory networks underlying the response of many different cellular systems to perturbations. Such a network analysis strategy using pathway information and data from multiple measurement platforms, tissues and species is a promising approach to elucidate the mechanistic underpinnings of complex diseases. Here, we present our views on the contributions that a systems approach can bring to the study of atherosclerosis, propose ways to tackle the complexity of the disease in a systems manner and review recent systems-level studies of the disease.

Alternate JournalEMBO Mol Med
PubMed ID20201031
PubMed Central IDPMC2992755
Grant ListHHSN272200700038C / / PHS HHS / United States
K25 HL098807-01 / HL / NHLBI NIH HHS / United States
R01 AI025032 / AI / NIAID NIH HHS / United States
HHSN272200700038C / AI / NIAID NIH HHS / United States
K25HL098807 / HL / NHLBI NIH HHS / United States
K25 HL098807 / HL / NHLBI NIH HHS / United States