TitleThiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice.
Publication TypeJournal Article
Year of Publication2003
AuthorsBermudez, LE, Reynolds, R, Kolonoski, P, Aralar, P, Inderlied, CB, Young, LS
JournalAntimicrobial agents and chemotherapy
Date Published2003 Aug

In vitro screening of thiacetazone derivatives indicated that two derivatives, SRI-286 and SRI-224, inhibited a panel of 25 Mycobacterium avium complex (MAC) isolates at concentrations of 2 micro g/ml or lower. In mice, SRI-224 and thiacetazone had no significant activity against the MAC in livers and spleens, but treatment with SRI-286 resulted in significant reduction of bacterial loads in livers and spleens. A combination of SRI-286 and moxifloxacin was significantly more active than single drug regimens in liver and spleen.