OREGON STATE UNIVERSITY
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| Title | Thiosemicarbazole (thiacetazone-like) compound with activity against Mycobacterium avium in mice. |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | Bermudez, LE, Reynolds, R, Kolonoski, P, Aralar, P, Inderlied, CB, Young, LS |
| Journal | Antimicrobial agents and chemotherapy |
| Volume | 47 |
| Issue | 8 |
| Pagination | 2685-7 |
| Date Published | 2003 Aug |
| Keywords | Thioacetazone |
| Abstract | In vitro screening of thiacetazone derivatives indicated that two derivatives, SRI-286 and SRI-224, inhibited a panel of 25 Mycobacterium avium complex (MAC) isolates at concentrations of 2 micro g/ml or lower. In mice, SRI-224 and thiacetazone had no significant activity against the MAC in livers and spleens, but treatment with SRI-286 resulted in significant reduction of bacterial loads in livers and spleens. A combination of SRI-286 and moxifloxacin was significantly more active than single drug regimens in liver and spleen. |