Title | Unraveling the basic biology and clinical significance of the chlamydial plasmid. |
Publication Type | Journal Article |
Year of Publication | 2011 |
Authors | Rockey, DD |
Journal | J Exp Med |
Volume | 208 |
Issue | 11 |
Pagination | 2159-62 |
Date Published | 2011 Oct 24 |
ISSN | 1540-9538 |
Keywords | Animals, Chlamydia Infections, Chlamydia trachomatis, DNA, Bacterial, Humans, Plasmids, Vaccines, Attenuated |
Abstract | Chlamydial plasmids are small, highly conserved, nonconjugative, and nonintegrative DNA molecules that are nearly ubiquitous in many chlamydial species, including Chlamydia trachomatis. There has been significant recent progress in understanding chlamydial plasmid participation in host-microbe interactions, disease, and immune responses. Work in mouse model systems and, very recently, in nonhuman primates demonstrates that plasmid-deficient chlamydial strains function as live attenuated vaccines against genital and ocular infections. Collectively, these studies open new avenues of research into developing vaccines against trachoma and sexually transmitted chlamydial infections. |
DOI | 10.1084/jem.20112088 |
Alternate Journal | J Exp Med |
PubMed ID | 22025500 |
PubMed Central ID | PMC3201210 |
Grant List | R21 AI069214 / AI / NIAID NIH HHS / United States RC1 AI086469 / AI / NIAID NIH HHS / United States AI069214 / AI / NIAID NIH HHS / United States AI086469 / AI / NIAID NIH HHS / United States |