TitleUnraveling the basic biology and clinical significance of the chlamydial plasmid.
Publication TypeJournal Article
Year of Publication2011
AuthorsRockey, DD
JournalJ Exp Med
Date Published2011 Oct 24
KeywordsAnimals, Chlamydia Infections, Chlamydia trachomatis, DNA, Bacterial, Humans, Plasmids, Vaccines, Attenuated

Chlamydial plasmids are small, highly conserved, nonconjugative, and nonintegrative DNA molecules that are nearly ubiquitous in many chlamydial species, including Chlamydia trachomatis. There has been significant recent progress in understanding chlamydial plasmid participation in host-microbe interactions, disease, and immune responses. Work in mouse model systems and, very recently, in nonhuman primates demonstrates that plasmid-deficient chlamydial strains function as live attenuated vaccines against genital and ocular infections. Collectively, these studies open new avenues of research into developing vaccines against trachoma and sexually transmitted chlamydial infections.

Alternate JournalJ Exp Med
PubMed ID22025500
PubMed Central IDPMC3201210
Grant ListR21 AI069214 / AI / NIAID NIH HHS / United States
RC1 AI086469 / AI / NIAID NIH HHS / United States
AI069214 / AI / NIAID NIH HHS / United States
AI086469 / AI / NIAID NIH HHS / United States