TitleVirulence-related Mycobacterium avium subsp hominissuis MAV_2928 gene is associated with vacuole remodeling in macrophages.
Publication TypeJournal Article
Year of Publication2010
AuthorsJha, SS, Danelishvili, L, Wagner, D, Maser, J, Li, Y-jun, Moric, I, Vogt, S, Yamazaki, Y, Lai, B, Bermudez, LE
JournalBMC microbiology
Date Published2010
KeywordsVirulence Factors

Mycobacterium avium subsp hominissuis (previously Mycobacterium avium subsp avium) is an environmental organism associated with opportunistic infections in humans. Mycobacterium hominissuis infects and replicates within mononuclear phagocytes. Previous study characterized an attenuated mutant in which the PPE gene (MAV_2928) homologous to Rv1787 was inactivated. This mutant, in contrast to the wild-type bacterium, was shown both to have impaired the ability to replicate within macrophages and to have prevented phagosome/lysosome fusion.