Title | Gene expression dynamics in the macrophage exhibit criticality. |
Publication Type | Journal Article |
Year of Publication | 2008 |
Authors | Nykter, M, Price, ND, Aldana, M, Ramsey, SA, Kauffman, SA, Hood, LE, Yli-Harja, O, Shmulevich, I |
Journal | Proc Natl Acad Sci U S A |
Volume | 105 |
Issue | 6 |
Pagination | 1897-900 |
Date Published | 2008 Feb 12 |
ISSN | 1091-6490 |
Keywords | Animals, Bone Marrow Cells, Gene Expression, Macrophages, Mice |
Abstract | Cells are dynamical systems of biomolecular interactions that process information from their environment to mount diverse yet specific responses. A key property of many self-organized systems is that of criticality: a state of a system in which, on average, perturbations are neither dampened nor amplified, but are propagated over long temporal or spatial scales. Criticality enables the coordination of complex macroscopic behaviors that strike an optimal balance between stability and adaptability. It has long been hypothesized that biological systems are critical. Here, we address this hypothesis experimentally for system-wide gene expression dynamics in the macrophage. To this end, we have developed a method, based on algorithmic information theory, to assess macrophage criticality, and we have validated the method on networks with known properties. Using global gene expression data from macrophages stimulated with a variety of Toll-like receptor agonists, we found that macrophage dynamics are indeed critical, providing the most compelling evidence to date for this general principle of dynamics in biological systems. |
DOI | 10.1073/pnas.0711525105 |
Alternate Journal | Proc Natl Acad Sci U S A |
PubMed ID | 18250330 |
PubMed Central ID | PMC2538855 |
Grant List | GM072855 / GM / NIGMS NIH HHS / United States GM070600 / GM / NIGMS NIH HHS / United States R01 GM072855 / GM / NIGMS NIH HHS / United States R21 GM070600 / GM / NIGMS NIH HHS / United States P50 GM076547 / GM / NIGMS NIH HHS / United States |