Carlson College of Veterinary Medicine

B. Wu, Moulton, H. M., Iversen, P. L., Jiang, J., Li, J., Li, J., Spurney, C. F., Sali, A., Guerron, A. D., Nagaraju, K., Doran, T., Lu, P., Xiao, X., and Lu, Q. Long, “Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer.”, Proceedings of the National Academy of Sciences of the United States of America, vol. 105, no. 39, pp. 14814-9, 2008.

N. Jearawiriyapaisarn, Moulton, H. M., Buckley, B., Roberts, J., Sazani, P., Fucharoen, S., Iversen, P. L., and Kole, R., “Sustained dystrophin expression induced by peptide-conjugated morpholino oligomers in the muscles of mdx mice.”, Molecular therapy : the journal of the American Society of Gene Therapy, vol. 16, no. 9, pp. 1624-9, 2008.

R. Burrer, Neuman, B. W., Ting, J. P. C., Stein, D. A., Moulton, H. M., Iversen, P. L., Kuhn, P., and Buchmeier, M. J., “Antiviral effects of antisense morpholino oligomers in murine coronavirus infection models.”, Journal of virology, vol. 81, no. 11, pp. 5637-48, 2007.

N. B. Marshall, Oda, S. K., London, C. A., Moulton, H. M., Iversen, P. L., Kerkvliet, N. I., and Mourich, D. V., “Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing.”, Journal of immunological methods, vol. 325, no. 1-2, pp. 114-26, 2007.

H. M. Moulton, Fletcher, S., Neuman, B. W., McClorey, G., Stein, D. A., Abes, S., Wilton, S. D., Buchmeier, M. J., Lebleu, B., and Iversen, P. L., “Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo.”, Biochemical Society transactions, vol. 35, no. Pt 4, pp. 826-8, 2007.

R. P. Wu, Youngblood, D. S., Hassinger, J. N., Lovejoy, C. E., Nelson, M. H., Iversen, P. L., and Moulton, H. M., “Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicity.”, Nucleic acids research, vol. 35, no. 15, pp. 5182-91, 2007.

R. Abes, Arzumanov, A. A., Moulton, H. M., Abes, S., Ivanova, G. D., Iversen, P. L., Gait, M. J., and Lebleu, B., “Cell-penetrating-peptide-based delivery of oligonucleotides: an overview.”, Biochemical Society transactions, vol. 35, no. Pt 4, pp. 775-9, 2007.

F. Debart, Abes, S., Deglane, G., Moulton, H. M., Clair, P., Gait, M. J., Vasseur, J. - J., and Lebleu, B., “Chemical modifications to improve the cellular uptake of oligonucleotides.”, Current topics in medicinal chemistry, vol. 7, no. 7, pp. 727-37, 2007.

Y. - J. Zhang, Wang, K. - Y., Stein, D. A., Patel, D., Watkins, R., Moulton, H. M., Iversen, P. L., and Matson, D. O., “Inhibition of replication and transcription activator and latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers.”, Antiviral research, vol. 73, no. 1, pp. 12-23, 2007.

S. Fletcher, Honeyman, K., Fall, A. M., Harding, P. L., Johnsen, R. D., Steinhaus, J. P., Moulton, H. M., Iversen, P. L., and Wilton, S. D., “Morpholino oligomer-mediated exon skipping averts the onset of dystrophic pathology in the mdx mouse.”, Molecular therapy : the journal of the American Society of Gene Therapy, vol. 15, no. 9, pp. 1587-92, 2007.

S. Abes, Moulton, H. M., Turner, J., Clair, P., Richard, J. P., Iversen, P., Gait, M. J., and Lebleu, B., “Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides.”, Biochemical Society transactions, vol. 35, no. Pt 1, pp. 53-5, 2007.

A. Amantana, Moulton, H. M., Cate, M. L., Reddy, M. T., Whitehead, T., Hassinger, J. N., Youngblood, D. S., and Iversen, P. L., “Pharmacokinetics, biodistribution, stability and toxicity of a cell-penetrating peptide-morpholino oligomer conjugate.”, Bioconjugate chemistry, vol. 18, no. 4, pp. 1325-31, 2007.

D. S. Youngblood, Hatlevig, S. A., Hassinger, J. N., Iversen, P. L., and Moulton, H. M., “Stability of cell-penetrating peptide-morpholino oligomer conjugates in human serum and in cells.”, Bioconjugate chemistry, vol. 18, no. 1, pp. 50-60, 2007.

G. McClorey, Moulton, H. M., Iversen, P. L., Fletcher, S., and Wilton, S. D., “Antisense oligonucleotide-induced exon skipping restores dystrophin expression in vitro in a canine model of DMD.”, Gene therapy, vol. 13, no. 19, pp. 1373-81, 2006.

G. McClorey, Fall, A. M., Moulton, H. M., Iversen, P. L., Rasko, J. E., Ryan, M., Fletcher, S., and Wilton, S. D., “Induced dystrophin exon skipping in human muscle explants.”, Neuromuscular disorders : NMD, vol. 16, no. 9-10, pp. 583-90, 2006.

B. W. Neuman, Stein, D. A., Kroeker, A. D., Moulton, H. M., Bestwick, R. K., Iversen, P. L., and Buchmeier, M. J., “Inhibition and escape of SARS-CoV treated with antisense morpholino oligomers.”, Advances in experimental medicine and biology, vol. 581, pp. 567-71, 2006.

J. Yuan, Stein, D. A., Lim, T., Qiu, D., Coughlin, S., Liu, Z., Wang, Y., Blouch, R., Moulton, H. M., Iversen, P. L., and Yang, D., “Inhibition of coxsackievirus B3 in cell cultures and in mice by peptide-conjugated morpholino oligomers targeting the internal ribosome entry site.”, Journal of virology, vol. 80, no. 23, pp. 11510-9, 2006.

S. Abes, Moulton, H. M., Clair, P., Prevot, P., Youngblood, D. S., Wu, R. P., Iversen, P. L., and Lebleu, B., “Vectorization of morpholino oligomers by the (R-Ahx-R)4 peptide allows efficient splicing correction in the absence of endosomolytic agents.”, Journal of controlled release : official journal of the Controlled Release Society, vol. 116, no. 3, pp. 304-13, 2006.

M. H. Nelson, Stein, D. A., Kroeker, A. D., Hatlevig, S. A., Iversen, P. L., and Moulton, H. M., “Arginine-rich peptide conjugation to morpholino oligomers: effects on antisense activity and specificity.”, Bioconjugate chemistry, vol. 16, no. 4, pp. 959-66, 2005.

B. W. Neuman, Stein, D. A., Kroeker, A. D., Churchill, M. J., Kim, A. M., Kuhn, P., Dawson, P., Moulton, H. M., Bestwick, R. K., Iversen, P. L., and Buchmeier, M. J., “Inhibition, escape, and attenuated growth of severe acute respiratory syndrome coronavirus treated with antisense morpholino oligomers.”, Journal of virology, vol. 79, no. 15, pp. 9665-76, 2005.

T. S. Deas, Binduga-Gajewska, I., Tilgner, M., Ren, P., Stein, D. A., Moulton, H. M., Iversen, P. L., Kauffman, E. B., Kramer, L. D., and Shi, P. Y., “Inhibition of flavivirus infections by antisense oligomers specifically suppressing viral translation and RNA replication.”, J Virol, vol. 79, no. 8, pp. 4599-609, 2005.

M. Alonso, Stein, D. A., Thomann, E., Moulton, H. M., Leong, J. C., Iversen, P., and Mourich, D. V., “Inhibition of infectious haematopoietic necrosis virus in cell cultures with peptide-conjugated morpholino oligomers.”, Journal of fish diseases, vol. 28, no. 7, pp. 399-410, 2005.

B. W. Neuman, Stein, D. A., Kroeker, A. D., Paulino, A. D., Moulton, H. M., Iversen, P. L., and Buchmeier, M. J., “Antisense morpholino-oligomers directed against the 5' end of the genome inhibit coronavirus proliferation and growth.”, Journal of virology, vol. 78, no. 11, pp. 5891-9, 2004.

H. M. Moulton and Moulton, J. D., “Arginine-rich cell-penetrating peptides with uncharged antisense oligomers.”, Drug discovery today, vol. 9, no. 20, p. 870, 2004.

H. M. Moulton, Nelson, M. H., Hatlevig, S. A., Reddy, M. T., and Iversen, P. L., “Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides.”, Bioconjugate chemistry, vol. 15, no. 2, pp. 290-9, 2004.