Lia Danelishvili, PhD

Associate Professor - Senior Research
Lia.Danelishvili@oregonstate.edu

Office: 541-737-6544 (voicemail)
Other: 541-737-6532 (reception)
Fax: 541-737-2730

Dryden Hall

Dryden Hall 208

450 SW 30th Street

450 SW 30th Street
Corvallis, OR 97331
Location: 
Building: 

Profile Field Tabs

At OSU
Affiliated with: 
Veterinary Medicine
Headquarters: 
OSU Main Campus
Research/Career Interests: 

My research is mainly focused on identification and characterization of virulence factors involved in the intracellular survival of Mycobacterium tuberculosis (the etiological agent of Tuberculosis) and Mycobacterium avium (prevalent pathogen in HIV-patients). I identify M. tuberculosis effector proteins secreted within the human macrophages and dissecting cellular processes, targeted by these effectors, through genetic, bioinformatics and proteomic approaches to gain insights and establish the mechanism of mycobacterium pathogenesis. I also study the bacterial response to anti-tuberculosis compounds (new and in use ones) to understand fundamental aspects of M. tuberculosis response to therapy. The multidisciplinary approaches employing bacterial genetics, high throughput screening libraries, gene knockout systems, cell biology, high-resolution microscopy and mass-spectrometric techniques are used in the laboratory. 

My Publications

2006

Journal Article

Y. Yamazaki, Danelishvili, L., Wu, M., Hidaka, E., Katsuyama, T., Stang, B., Petrofsky, M., Bildfell, R., and Bermudez, L. E., “The ability to form biofilm influences Mycobacterium avium invasion and translocation of bronchial epithelial cells.”, Cell Microbiol, vol. 8, no. 5, pp. 806-14, 2006.
D. Patel, Danelishvili, L., Yamazaki, Y., Alonso, M., Paustian, M. L., Bannantine, J. P., Meunier-Goddik, L., and Bermudez, L. E., “The ability of Mycobacterium avium subsp. paratuberculosis to enter bovine epithelial cells is influenced by preexposure to a hyperosmolar environment and intracellular passage in bovine mammary epithelial cells.”, Infection and immunity, vol. 74, no. 5, pp. 2849-55, 2006.

2005

Journal Article

L. Danelishvili, Wu, M., Young, L. S., and Bermudez, L. E., “Genomic approach to identifying the putative target of and mechanisms of resistance to mefloquine in mycobacteria.”, Antimicrobial agents and chemotherapy, vol. 49, no. 9, pp. 3707-14, 2005.
L. Danelishvili, Wu, M., Young, L. S., and Bermudez, L. E., “Genomic approach to identifying the putative target of and mechanisms of resistance to mefloquine in mycobacteria.”, Antimicrob Agents Chemother, vol. 49, no. 9, pp. 3707-14, 2005.

2004

Journal Article

L. Danelishvili, Poort, M. J., and Bermudez, L. E., “Identification of Mycobacterium avium genes up-regulated in cultured macrophages and in mice.”, FEMS microbiology letters, vol. 239, no. 1, pp. 41-9, 2004.
L. Danelishvili, Poort, M. J., and Bermudez, L. E., “Identification of Mycobacterium avium genes up-regulated in cultured macrophages and in mice.”, FEMS Microbiol Lett, vol. 239, no. 1, pp. 41-9, 2004.

2003

Journal Article

L. Danelishvili and Bermudez, L. E., “Role of type I cytokines in host defense against Mycobacterium avium infection.”, Curr Pharm Des, vol. 9, no. 1, pp. 61-5, 2003.
L. Danelishvili, McGarvey, J., Li, Y. -jun, and Bermudez, L. E., “Mycobacterium tuberculosis infection causes different levels of apoptosis and necrosis in human macrophages and alveolar epithelial cells.”, Cell Microbiol, vol. 5, no. 9, pp. 649-60, 2003.
L. Danelishvili and Bermudez, L. E., “Role of type I cytokines in host defense against Mycobacterium avium infection.”, Current pharmaceutical design, vol. 9, no. 1, pp. 61-5, 2003.
L. Danelishvili, McGarvey, J., Li, Y. -jun, and Bermudez, L. E., “Mycobacterium tuberculosis infection causes different levels of apoptosis and necrosis in human macrophages and alveolar epithelial cells.”, Cellular microbiology, vol. 5, no. 9, pp. 649-60, 2003.

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