Natalia Shulzhenko, MD, PhD

Associate Professor - Immunology
natalia.shulzhenko@oregonstate.edu

Office: 541-737-1051

Dryden Hall

Dryden Hall 208

450 SW 30th Street

450 SW 30th Street
Corvallis, OR 97331
Location: 
Building: 

Profile Field Tabs

At OSU
Affiliated with: 
Veterinary Medicine
Headquarters: 
OSU Main Campus
Research/Career Interests: 

Publications

 

The Shulzenko lab is interested in understanding how cells of the immune system communicate with other host systems and the resident microorganisms (microbiota) in complex organisms in health and disease. This co-existence is beneficial for both sides but has to be tightly regulated in order to prevent disease development. In order to disclose the mechanisms of these physiological and associated pathological processes, the lab uses a systems approach and analyzes host and microbiota simultaneously. This is done through host transcriptome profiling and global microbiome analysis by next generation sequencing to identify the key regulators of the process. These findings are further validated by directed perturbations of host and microbiota using gnotobiotic mice, i.e. those colonized with defined microbiota. Lab’s recent work in chronic enteropathy of immunodeficient hosts (human and mouse) and in type 2 diabetes focuses on finding microbiota members that can be harmful or beneficial for these diseases.

Morgun & Shulzhenko Labs

EDUCATION

2002: Ph. D. Degree, Federal University of Sao Paulo - Escola Paulista de Medicina, São Paulo, SP, Brazil. 
1995: M.D. Diploma with honors, Kharkiv Medical University, Kharkiv, Ukraine.

EXPERIENCE

2018-Present: Associate Professor, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR

2012-2018: Assistant Professor, Carlson College of Veterinary Medicine, Oregon State University, Corvallis, OR

2011-2012: Research Assistant Professor, College of Pharmacy, Oregon State University, Corvallis, OR

2005-2011: Postdoctoral Fellow, T Cell Tolerance and Memory Section, Laboratory of Cellular and Molecular Immunology (LCMI), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA

2001-2005: Staff Scientist/Supervisor of Molecular Biology Section, Immunogenetics Division, Association of the Incentive Fund for Psycho-pharmacology (AFIP), Federal University of Sao Paulo, São Paulo, Brazil.

My Publications

2021

Journal Article

R. R. Rodrigues, Gurung, M., Li, Z., Garcia-Jaramillo, M., Greer, R., Gaulke, C., Bauchinger, F., You, H., Pederson, J. W., Vasquez-Perez, S., White, K. D., Frink, B., Philmus, B., Jump, D. B., Trinchieri, G., Berry, D., Sharpton, T. J., Dzutsev, A., Morgun, A., and Shulzhenko, N., “Transkingdom interactions between Lactobacilli and hepatic mitochondria attenuate western diet-induced diabetes.”, Nat Commun, vol. 12, no. 1, p. 101, 2021.

2020

Journal Article

Y. Zhang, Bobe, G., Revel, J. S., Rodrigues, R. R., Sharpton, T. J., Fantacone, M. L., Raslan, K., Miranda, C. L., Lowry, M. B., Blakemore, P. R., Morgun, A., Shulzhenko, N., Maier, C. S., Stevens, J. F., and Gombart, A. F., “Improvements in Metabolic Syndrome by Xanthohumol Derivatives Are Linked to Altered Gut Microbiota and Bile Acid Metabolism.”, Mol Nutr Food Res, vol. 64, no. 1, p. e1900789, 2020.
M. Gurung, Li, Z., You, H., Rodrigues, R., Jump, D. B., Morgun, A., and Shulzhenko, N., “Role of gut microbiota in type 2 diabetes pathophysiology.”, EBioMedicine, vol. 51, p. 102590, 2020.
H. M. Kahalehili, Newman, N. K., Pennington, J. M., Kolluri, S. K., Kerkvliet, N. I., Shulzhenko, N., Morgun, A., and Ehrlich, A. K., “Dietary Indole-3-Carbinol Activates AhR in the Gut, Alters Th17-Microbe Interactions, and Exacerbates Insulitis in NOD Mice.”, Front Immunol, vol. 11, p. 606441, 2020.
B. Koscsó, Kurapati, S., Rodrigues, R. R., Nedjic, J., Gowda, K., Shin, C., Soni, C., Ashraf, A. Zaffran, Purushothaman, I., Palisoc, M., Xu, S., Sun, H., Chodisetti, S. Babu, Lin, E., Mack, M., Kawasawa, Y. Imamura, He, P., Rahman, Z. S. M., Aifantis, I., Shulzhenko, N., Morgun, A., and Bogunovic, M., “Gut-resident CX3CR1 macrophages induce tertiary lymphoid structures and IgA response in situ.”, Sci Immunol, vol. 5, no. 46, 2020.
I. E. Logan, Bobe, G., Miranda, C. L., Vasquez-Perez, S., Choi, J., Lowry, M. B., Sharpton, T. J., Morgun, A., Maier, C. S., Stevens, J. F., Shulzhenko, N., and Gombart, A. F., “Germ-Free Swiss Webster Mice on a High-Fat Diet Develop Obesity, Hyperglycemia, and Dyslipidemia.”, Microorganisms, vol. 8, no. 4, 2020.

2019

Journal Article

K. E. Lawrence, Lam, K. C., Morgun, A., Shulzhenko, N., and Löhr, C. V., “Effect of temperature and time on the thanatomicrobiome of the cecum, ileum, kidney, and lung of domestic rabbits.”, J Vet Diagn Invest, vol. 31, no. 2, pp. 155-163, 2019.

2018

Journal Article

R. R. Rodrigues, Shulzhenko, N., and Morgun, A., “Transkingdom Networks: A Systems Biology Approach to Identify Causal Members of Host-Microbiota Interactions.”, Methods Mol Biol, vol. 1849, pp. 227-242, 2018.
N. Shulzhenko, Dong, X., Vyshenska, D., Greer, R. L., Gurung, M., Vasquez-Perez, S., Peremyslova, E., Sosnovtsev, S., Quezado, M., Yao, M., Montgomery-Recht, K., Strober, W., Fuss, I. J., and Morgun, A., “CVID enteropathy is characterized by exceeding low mucosal IgA levels and interferon-driven inflammation possibly related to the presence of a pathobiont.”, Clin Immunol, vol. 197, pp. 139-153, 2018.
K. Chi Lam, Vyshenska, D., Hu, J., Rodrigues, R. Rosario, Nilsen, A., Zielke, R. A., Brown, N. Samuel, Aarnes, E. - K., Sikora, A. E., Shulzhenko, N., Lyng, H., and Morgun, A., “Transkingdom network reveals bacterial players associated with cervical cancer gene expression program.”, PeerJ, vol. 6, p. e5590, 2018.

Pages